Diffuse Large B-Cell Lymphoma (DLBCL) | Aggressive B-Cell Non-Hodgkin’s Lymphoma

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Hematological malignancies are subdivided into leukemias, lymphomas, and multiple myeloma.

Lymphoma can be Hodgkin or Non-Hodgin's (such as DLBCL).

Diffuse Large B-cell lymphoma (DLBCL) is an aggressive Non-Hodgkin's lymphoma (NHL)...It's the most common NHL

To diagnose, you need a core needle biopsy or an excisional biopsy of the lymph node

Uric acid levels can be high---Give allopurinol (Xanthine oxidase inhibitor).

Staging of cancer is important (Ann-Arbor classification based on history, physical exam and CT scan)

Treatment: Combination Chemotherapy (R-CHOP) regimen.

Tumor lysis syndrome can ensue.

PET scan is helpful.


The lymph node is a bean-shaped body (not a gland) that interrupts the flow of lymph through the lymphatic vessels.

Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin).

Lymphocyte activation and differentiation occur in the lymph node.

Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems.

Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct.

Lymph slows down when it passes in lymph nodes.

Lacteals are a special type of lymph, they are milky because they contain chylomicrons.

Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).


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