CAR-T Cells: Engineered Cancer Killers, Mechanism of Action

Chimeric Antigen Receptor, or CAR-T cell therapy, is a revolutionary treatment for blood cancers such as leukaemias and lymphomas. The process involves engineering a patient’s own immune T cells to express Chimeric Antigen Receptors, or CARs on the cell surface. When the CAR-T cells are re-infused into the patient, they multiply rapidly and the CARs enable them to specifically seek and destroy cancer cells throughout the body. For some patients this has proven to be a miracle treatment when all other options have been exhausted.

This production explains how cancer cells can avoid detection by our immune cells. We then learn how our immune cells can be super charged by CAR-T technology and how this works at the molecular and cellular levels using 3D animation and ground-breaking microscopy techniques.

The production won the Premier Award and the Medical Education Award in the Interactive Learning and Website division at BioImages 22, a visual media competition showcasing the life sciences and medicine, by the BioCommunications Association.'