Total Synthesis of the Neurotoxic Natural Product Tetrodotoxin with Dr. David Konrad

In this Research Spotlight episode, Dr. David Konrad (LMU Munich) shares his work on the development of a total synthesis of tetrodotoxin in the Trauner group.

Key reference:
Science 2022, 377, 411-415.
http://doi.org/10.1126/science.abn0571

Additional references (in order of appearance):
Appl. Environ. Microbiol. 1987, 53, 1714-1715. Nippon Suisan Gakkaishi 1985, 51, 1175-1180. Mar. Drugs 2010, 8, 577-593.
J. Am. Chem. Soc. 1972, 94, 9219–9221.
J. Org. Chem. 2005, 70, 7496–7504.
J. Am. Chem. Soc. 2003, 125, 11510–11511.
Angew. Chem. Int. Ed. 2004, 43, 4782–4785.
Synlett 2019, 30, 383-386.
Bull. Chem. Soc. Jpn. 2010, 83, 279–287.
Org. Lett. 2022, 23, 514-518.
J. Am. Chem. Soc. 1999, 121, 11680-11683. J. Am. Chem. Soc. 2000, 122, 4304–4309. J. Org. Chem. 2003, 68, 7123–7125.
Bull. Chem. Soc. Jpn. 2010, 43, 3332–3341.

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