Скачать или смотреть 7. Connective Tissue: Fibronectin & Laminin: Structure & Function | MBBS 1st year | USMLE step 1

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Connective Tissue Biochemistry | Fibronectin & Laminin | Structure, Function & Clinical Aspects | MBBS | USMLE Step 1

👋 Hey future doctors and biochem learners! Beyond collagen and elastin, the extracellular matrix (ECM) contains special glycoproteins like Fibronectin and Laminin, which act as the “biological glue” holding cells together and anchoring them to the ECM. They regulate cell adhesion, migration, growth, and differentiation — making them crucial for both normal development and disease processes.

This lecture explains the structure, functions, and clinical relevance of Fibronectin & Laminin, essential for MBBS, NEET PG, FMGE, and USMLE Step 1 preparation. 🧬📚

🌟 Fibronectin

Structure: Large glycoprotein, exists as a dimer linked by disulfide bonds.

Domains: Specific binding sites for collagen, fibrin, heparin, and integrins.

Functions:
• Cell adhesion & migration.
• Wound healing (acts as a scaffold for tissue repair).
• Embryonic development (cell migration guidance).
• Provides a link between cells and collagen in the ECM.

Clinical 🩺:
• Overexpression in cancer → promotes tumor spread & metastasis.
• Defects affect wound healing.

🌟 Laminin

Structure: Cross-shaped glycoprotein with three chains (α, β, γ).

Location: Major component of the basement membrane.

Functions:
• Anchors epithelial cells to the basement membrane.
• Promotes cell differentiation and migration.
• Interacts with type IV collagen and integrins.

Clinical 🩺:
• Defects linked to muscular dystrophies.
• Tumor cells often use laminin receptors for invasion & metastasis.

⚙️ Clinical Integration

Fibronectin & Laminin = key ECM proteins bridging cells, collagen, and basement membrane.

Important in:
• Wound healing.
• Cancer metastasis.
• Fibrosis & tissue remodeling.
• Muscular dystrophies & basement membrane diseases.

🎯 Exam Integration

Fibronectin: wound healing, metastasis, cell adhesion.

Laminin: basement membrane anchoring, muscular dystrophies.
👉 High-yield for both direct recall and case-based clinical questions in USMLE Step 1 & NEET PG.

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❓Want us to make a separate lecture on Glycosaminoglycans & Proteoglycans (e.g., heparan sulfate, chondroitin, hyaluronic acid, keratan sulfate) for the next part of your Connective Tissue series? Drop your request in the comments below! 😊

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