221129 UNIST BME Seminar, Translational neurophotonics (Euiheon Chung)

#Neurophotonics #Euiheon_Chung #Biophotonics #GIST

Translational neurophotonics:
Imaging and Manipulating Brain Diseases with Light

Abstract: Neurophotonics is a branch of biophotonics implementing methods for imaging and manipulating the brain and related activities. Translational neurophotonics describes the application of biophotonic techniques in clinical environments treating neurological diseases by revealing neural and cerebrovascular networks encompassing microscopic interactions and macroscopic neuroelectric activities. In particular, in vivo imaging of animal disease models should provide a unique window to visualize the brain structure and functioning mechanisms for developing translational therapeutic strategies. This talk will discuss a novel, cutting-edge optical imaging approaches, including quantitative laser speckle imaging and intravital volumetric microscopy, with which an ischemic stroke animal model was examined. Optogenetic control of capillary blood vessels via neurovascular coupling will also be presented and discussed. The translational neurophotonics field is highly active in deciphering neural mechanisms underlying cerebrovascular diseases and therapeutic neuromodulation. Relevant projects and future directions will be outlined and discussed, including therapeutic photobiomodulation in the newly developed rodent ischemic model of olfactory dysfunctions.