Скачать или смотреть MedChem Essentials: Metabolism Part 1 - Introduction - Phase 1

MedChem Essentials is a series of scientific seminars designed to introduce the most important aspects of medicinal chemistry to chemists of other specialties and scientists working in the life sciences industry and academia.

In this episode, we take a closer look at Phase 1 metabolism in drug discovery. We introduce the key enzymes involved—such as cytochrome P450s, flavin-containing monooxygenases (FMOs), monoamine oxidases (MAOs), and aldehyde oxidase (AO)—and discuss how they contribute to drug clearance. Real-world case studies highlight the challenges of predicting human metabolism and the need for early identification of metabolic liabilities.

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