Predicting Familial Cavernoma Progression using BioMarkers

Predicting Familial Cavernoma Progression using BioMarkers

Presentations by Associate Professor Peetra Magnusson, Professor Roberto Latini, Dr Francesca Lazzaroni and Favour Onyeogaziri.

For references and comments, see below,

A cavernoma is made up of abnormal blood vessels and can be found in the brain and/or spinal cord and looks like a raspberry.

1 person in 600, in the UK, has a brain cavernoma without symptoms (asymptomatic). This equates to roughly 90,000 people – enough to fill Wembley Stadium. A spinal cavernoma is rarer than a brain cavernoma.

For more information about Cavernoma Alliance UK, please visit https://cavernoma.org.uk/

This is a recording of one of our webinars given by our members, guests and medical experts throughout 2024.


The first presentation by Francesca Lazzaroni will be about this article: https://www.sciencedirect.com/science...

This is the article Roberto is referring to: https://www.nature.com/articles/s4146...

Angiogensis is the formation of new blood vessels.

Proteomics is the study of the interactions, function, composition, and structures of proteins and their cellular activities.

Endothelial cells form a single cell layer that lines all blood vessels and regulates exchanges between the bloodstream and surrounding tissues. Signals from these cells organize the growth and development of connective tissues that form the surrounding layers of the blood vessel wall.

Proteins are molecules of amino acids. Proteins are needed for the body to function properly. They are the basis of body structures, such as skin and hair and other substances such as enzymes and antibodies.

Fibroblasts are a type of cell that contributes to the formation of connective tissue.

Control = healthy sample

Hypoxia is a state in which oxygen is not available in sufficient amounts

rupture = haemorrhage/bleeding

Microbiome is the community of microorganisms (such as bacteria, fungi, viruses) that naturally live on our bodies and inside us. Gut microbiome bacteria can help with digestion, destroy harmful bacteria and help control your immune system.


https://ccmregistry.org/ is the American Cavernoma Registry.