Synthesis Workshop: Selective Dearomatization of Phenols with Prof. Sarah Wengryniuk (Episode 71)

In this Research Spotlight episode, Prof. Sarah Wengryniuk joins us to talk about selective dearomatization of phenols using hypervalent iodine reagents. This episode has been made possible through a collaboration with Thieme Chemistry (Twitter: @thiemechemistry) and is made in recognition of Prof. Sarah Wengryniuk as a recipient of the Thieme Chemistry Journal Award.

Key reference:
Synlett, 2021, 32, 752.
https://doi.org/10.1055/s-0037-1610760

Other references (in order of appearance):
For recent review on aerobic Cu-catalysis approaches see: Synlett, 2015, 26, 2731.
Magdziak, D. et. al. Org. Lett., 2002, 4, 285.
For reviews on I(V) reagents see: J. Org. Chem. 2011, 76, 1185.; Tetradedron 2010, 7659.; ACIE, 2011, 50, 1524.
Kaur, et. al. Org. Biomol. Chem., 2020, 18, 1117.
Seminal report from Pettus: Org. Lett., 2002, 4, 285.
For reviews on I(V) reagents see: J. Org. Chem. 2011, 76, 1185.; Tetradedron 2010, 7659.; ACIE, 2011, 50, 1524.
Zhdankin, V. V. et al. Tetradedron Lett. 2002, 43, 5735.
Seminal report on N-HVI see: Weiss, R. et. al. Angew. Chem. Int. Ed. 1994, 33, 891.; For a useful review on N-HVI see: Corbo, R. et al. Coord. Chem. Rev. 2018, 375, 69.
Xiao, X. et. al. J. Org. Chem. 2021, 86, 6566.
Seminal report on N-ligated I(V) reagents : Zhdankin, V. V. et al. Tetradedron Lett. 2002, 43, 5735.
Xiao, X. et al., Angew. Chem. Int. Ed. 2019, 58, 16181.
J. Org. Chem. 2021, 86, 12237.