Скачать или смотреть Researchers at IOCB Prague tame a deadly fungus that threatens immunocompromised patients

A team led by Prof. Jan Konvalinka has developed a compound that destroys the yeast Cryptococcus neoformans – a fungus which is life-threatening for people with weakened immune systems – in laboratory settings.

Researchers at IOCB have created a new method for synthesizing macrocyclic compounds – small, ring-shaped molecules. Using this approach, they discovered a highly promising compound that kills the fungus in lab cultures, does not harm human cells, and is effectively entering the bloodstream when administered orally, as demonstrated in mice.

The study was published in the prestigious Journal of Medicinal Chemistry.

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Original article:
Kryštůfek, R.; Verner, V.; Šácha, P.; Hadzima, M.; Trajhan, F.; Starková, J.; Tloušťová, E.; Dvořáková, A.; Pecina, A.; Brynda, J.; Chalupský, K.; Hájek, M.; Boucher, M. J.; Majer, P.; Řezáč, J.; Madhani, H. D.; Craik, C. S.; Konvalinka, J. “On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents”. J. Med. Chem. 2025. https://doi.org/10.1021/acs.jmedchem....