Pregabalin (Lyrica) : Uses, dosage and side effects

Pregabalin 75 mg and 150 mg capsules are used to treat neuropathic pain. It is well known by its brand name, LYRICA, and it is classified as an antiepileptic drug (AED). It is structurally related to GABA, which is why we can observe the term GABA within its name. But interestingly, pregabalin does not act as GABA. Even though it is structurally related to GABA, it still doesn’t bind to GABA receptors. Then how can pregabalin affect neuronal conduction? Pregabalin reduces the opening of calcium channels, thereby reducing impulse conduction.

One of the important indications for pregabalin is the treatment of neuropathic pain. Elevated levels of glucose in diabetic patients may result in damage to neurons, leading to a loss of control and excessive firing of nociceptive neurons, resulting in neuropathic pain. Pregabalin can reduce neuropathic pain by reducing the propagation of pain signals to the brain.


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