Скачать или смотреть CAR T-cells for B-ALL- Video Abstract ID 146309

Video abstract of review paper “The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL” published in the open access journal Therapeutics and Clinical Risk Management by Forsberg MH, Das A, Saha K, et al.

Abstract: Recent advancements in immuno-oncology have resulted in the generation of novel therapies such as chimeric antigen receptor (CAR) T cells, which have revolutionized the treatment of pediatric patients with relapsed or refractory B-cell acute lymphoblastic leukemia. The journey of tisagenlecleucel (formerly CTL019) from early preclinical success to the US Food and Drug Administration approval is summarized in this review. Strategies that are currently being investigated to improve the efficacy and safety profile of CAR T-cells are also explored, as well as the factors contributing to the present state of patient access to CAR T therapy.

Read the review paper here: https://www.dovepress.com/the-potenti...