Скачать или смотреть Siderophores bioinorganic chemistry structure function animation bacteria NTA CSIR NET GATE IIT JAM

#siderophores #bioinorganic #csirnetchemistry #MSc_chemistry
‪@AdiChemAdi‬
Structure and function of siderophores (Msc chemistry) - specialized chelating molecules produced by microbes and some plants to absorb iron from their environment.
I am going to discuss the bioinorganic perspective of the subject.
I am aditya vardhan. founder of adichemistry.com, Warangal.

==============
In general, microbes and plants absorb soluble ferrous ions from their environment through their cell membranes. I am not showing the detailed mechanism of absorption that involves receptors to keep things simple.

===============

However, when the ferrous ions are oxidized to ferric ions and subsequent formation of insoluble ferric hydroxide creates extreme iron deficiency. The insoluble ferric hydroxide cannot be absorbed by the cells.

==========
To overcome this situation, the microbes secrete specialized molecules known as siderophores. They bind the ferric ions through the complex formation and transport them into the cells through the specific receptors of cell membranes.
==================
The siderophores are the multidentate anionic ligands that help in the transport of iron under extreme iron deficiency conditions.
============
Importantly, they are nonprotein low molecular weight organic molecules.
=========
Siderophores can fully satisfy the octahedral geometry requirements of iron without significant distortion and can bind flexibly.
==========
They capture Fe3+, stabilize, and transport; then release wherever required.
==============
Release of iron occurs by reduction to Fe2+ enzymatically and dissociation from the siderophore.
========