nanoHUB-U Biodesign L3.2: Gene Circuits - Simple Models of Gene Expression

Table of Contents:
00:00 L3.2: Simple Models of Gene Expression
00:12 In this lecture
00:34 Effect of Transcription Factor X on Gene Y
02:19 simple deterministic model
03:14 Consumption
05:23 Generation: Hill function model
09:31 Hill function model of gene activation
11:31 Hill function model of gene activation
14:47 governing rate equation for protein Y
16:56 governing equation for simple activation
18:57 Response time to turn ON
21:15 OFF kinetics
22:39 End with a Challenge
23:48 Next up

This video is part of the nanoHUB-U course "Biological Engineering: Cellular Design Principles" currently offered on nanoHUB-U (https://nanohub.org/courses/biod) or on EdX (https://www.edx.org/course/biological...)

Cellular Design Principles is a five week course that explores the design principles underlying mechanisms of cellular and biomolecular functions such as cell architecture, energy storage and conversion, sensing and signaling, communication, time keeping, molecular synthesis, memory, and motility. Emphasis will be placed on the chemical, physical, and mathematical features that determine the performance of the biological device. Topics cover both cellular/biochemical processes and molecular/genetic circuits. Examples are presented from reverse engineering of natural systems and design of new synthetic systems.