Скачать или смотреть New molecules from IOCB Prague decrease appetite, protect the brain against Alzheimer disease

Scientists on the team of Dr Lenka Maletínská have developed a promising new compound derived from one of the peptides naturally occurring in the brain. Its application may contribute to the addressing of two major health challenges of the modern days: obesity and Alzheimer's disease.

The neuropeptide CART is primarily associated with the regulation of food intake. Its modified version, created at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, shows better stability and is more effective. It suppresses appetite and protects the brain by reducing the pathogenicity of the tau protein, which is associated with the dreaded Alzheimer's disease. The results of the research have been published in the European Journal of Pharmacology.

Česká verze ►    • Nové molekuly z ÚOCHB snižují chuť k jídlu...   ⤵
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Original article: Charvát, V.; Strnadová, A.; Myšková, A.; Sýkora, D.; Blechová, M.; Železná, B.; Kuneš, J.; Maletínská, L.; Pačesová, A. Lipidized analogues of the anorexigenic CART (cocaine – and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity. Eur. J. Pharmacol. 2024, 980, https://doi.org/10.1016/j.ejphar.2024...