Скачать или смотреть 8. Plasma Proteins | Functions, Genetic Deficiencies & Proteinuria l Biochemistry USMLE Step 1

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning  

Plasma Proteins | Functions, Genetic Deficiencies & Proteinuria | Medical Biochemistry | MBBS | USMLE Step 1

👋 Hey future doctors and biochem learners! Plasma proteins are not just passive molecules in the blood — they are essential for maintaining osmotic balance, transporting substances, defending the body, and enabling clotting.

In this lecture, we’ll cover the functions of plasma proteins, their important genetic deficiencies, and the concept of proteinuria, making it highly relevant for MBBS, NEET PG, FMGE, and USMLE Step 1. 🧬📚

🌟 Functions of Plasma Proteins

Albumin
• Maintains colloid osmotic pressure.
• Transports bilirubin, fatty acids, drugs, hormones.
• Clinical: Hypoalbuminemia → edema (e.g., nephrotic syndrome, liver disease).

Globulins
• α1-antitrypsin: protease inhibitor (deficiency → emphysema, liver disease).
• Ceruloplasmin: copper transport (deficiency → Wilson’s disease).
• Haptoglobin: binds free hemoglobin.
• Transferrin: iron transport.
• Immunoglobulins (IgG, IgA, IgM, IgE, IgD): humoral immunity.

Fibrinogen
• Clotting factor → converted to fibrin in coagulation.

🌟 Genetic Deficiencies of Plasma Proteins

α1-Antitrypsin deficiency → emphysema, cirrhosis.

Ceruloplasmin deficiency → Wilson’s disease (copper accumulation).

Transferrin abnormalities → iron overload or anemia.

Hypoalbuminemia → Kwashiorkor, liver failure, nephrotic syndrome.

Agnammaglobulinemia → recurrent infections.

🌟 Proteinuria

Definition: Presence of abnormal proteins in urine.

Types:
• Glomerular proteinuria: defective glomerular filtration barrier → albuminuria (e.g., nephrotic syndrome).
• Tubular proteinuria: defective reabsorption of filtered proteins (e.g., Fanconi syndrome).
• Overflow proteinuria: excess plasma proteins overwhelm kidney reabsorption (e.g., multiple myeloma → Bence-Jones proteins).
• Post-renal proteinuria: due to urinary tract inflammation or infection.

Clinical Importance:
• Nephrotic syndrome: massive albuminuria, edema, hyperlipidemia.
• Multiple myeloma: Bence-Jones proteins detectable by heat precipitation/electrophoresis.

🎯 Exam Integration

Albumin = osmotic pressure + transport.

Genetic deficiency α1-antitrypsin → emphysema.

Proteinuria = glomerular vs tubular vs overflow (case-based Qs).
👉 A must-know topic that connects biochemistry with clinical medicine.

👉 Don’t forget to Subscribe and tap the 🔔 bell for more high-yield medical biochemistry lectures!

👍 If this lecture helps you, give it a like and share with your classmates. Your support motivates us to keep producing simplified, exam-focused content. 🙌

❓Want us to create a separate lecture on Nephrotic Syndrome & Proteinuria Mechanisms with integrated pathology and clinical cases? Drop your request in the comments below! 😊

#PlasmaProteins #Albumin #Globulins #Fibrinogen #Proteinuria #MedicalBiochemistry #USMLEStep1 #MBBSLectures #FMGE #NEETPG #Alpha1Antitrypsin #Ceruloplasmin #WilsonDisease #MultipleMyeloma #NephroticSyndrome #BenceJonesProtein #BiochemistryLecture #MedicalStudents