Primary Cutaneous PEComa...Explained by a Dermatopathologist

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

PEComas are an odd family of tumors with melanocytic and myogenic immunophenotype. They can arise in the visceral organs, soft tissue, or, very rarely, skin. Primary cutaneous PEComas have some features that differ from many of their deep counterparts, including a distinct clear cell nest-like growth pattern and a tendency to lack desmin or actin staining in around half of cases. Watch the video to learn more including how to work up these case and exclude other entities in the differential diagnosis.

Additional reading:
Our series of 5 primary cutaneous PEComas in Journal of Cutaneous Pathology: https://www.ncbi.nlm.nih.gov/pubmed/2...
Excellent paper by Phil LeBoit's group: https://www.ncbi.nlm.nih.gov/pubmed/2...
Early paper by Mentzel's group: https://www.ncbi.nlm.nih.gov/pubmed/1...
Great paper on deep soft tissue & gynecologic PEComas by Folpe et al: https://www.ncbi.nlm.nih.gov/pubmed/1...

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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