Скачать или смотреть Precision Medicine in Oncology: Cutting-Edge Techniques Explained.

In this episode, we have two very special guests who are going to shed light on a developing field: the genotyping and analysis of circulating DNA in the detection and follow-up of cancer. This is part of the technologies in precision medicine that could contribute to improving the effectiveness of treatments. We are joined by Dr. Lilian Siu, a senior medical oncologist at the Princess Margaret Cancer Centre since 1998, and a Professor of Medicine at the University of Toronto since 2009. She is the Director of the Phase I Program and Co-Director of the Bras and Family Drug Development Program at the Princess Margaret Cancer Centre, and holds the BMO Chair in Precision Genomics (2016-2026). Dr. Siu’s major research focus is in the area of new anticancer drug development, particularly with respect to phase I trials and head and neck malignancies.

Our other guest, Dr. David Cescon, is a breast medical oncologist and clinician-scientist at the Princess Margaret Cancer Centre. His research integrates laboratory and clinical studies, focused on identifying breast cancer therapeutic vulnerabilities and determinants of drug response and resistance. Leveraging pre-clinical model platforms and genomic tools, including liquid biopsy, the overarching goal of his work is to advance the delivery of precision therapy to improve breast cancer outcomes through both the prevention and treatment of metastatic disease.

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Reference: Cescon DW, Bratman SV, Chan SM, Siu LL. Circulating tumor DNA and liquid biopsy in oncology. Nat Cancer. 2020 Mar;1(3):276-290. doi: 10.1038/s43018-020-0043-5. Epub 2020 Mar 20. PMID: 35122035.

Timelapse:
00:00 Introduction
00:34 Start of the episode
01:48 The motivation behind this field of research
05:40 Genotyping of circulating DNA (in blood) vs. traditional biopsy
08:39 What are the limitations of analyzing circulating DNA?
10:48 Clinical application of this technique
16:16 How sensitive is ctDNA, and how sensitive should it be to be used as a diagnostic tool?
18:34 Is it applicable for screening or follow-up?
29:13 Is this test considered in clinical settings today?
35:13 About cost-effectiveness
40:11 What’s next in research?
42:27 Final comments

Disclosure:
The content of this podcast is purely academic in nature and is intended for educational and informational purposes only. The material discussed does not represent or reflect the views, opinions, or policies of the Medical College of Georgia, and the information presented should not be construed as medical advice or guidance. Always consult with a qualified healthcare professional for any medical concerns or questions. I'd like to explicitly state that I have no endorsement from, affiliations with, or financial interests in any pharmaceutical companies or medical device manufacturers. Any mention of medications, devices, or treatments is made solely within the context of literature and academic discussion.