Скачать или смотреть Dieter Braun: Tracking the first evolutionary steps in non-equilibrium settings

Dieter Braun's talk at the workshop on nucleic acids, synthetic biology and artificial life: https://www.imperial.ac.uk/principles...

We have driven the first steps of molecular evolution with non-equilibrium settings, often temperature gradients, but also with a recent focus on air-water interfaces. These settings accumulate molecules, select them for length, enable strand separation and allow continuous feeding through bulk solutions. Using sequencing, we see diverse pathways in sequence space that are able to create structure from randomness. These experimental findings make us better understand what are the pitfalls towards open ended evolution. In many cases still, these studies are performed with the help of a protein, but we converge towards RNA only experiment, driven by hybridization, gravity, temperature and hopefully, autocatalysis.