Скачать или смотреть Tumor Microenvironments, Target Antigens, & Immunotherapy - The Braun Lab at Yale School of Medicine

For more information on David Braun or #YaleSchoolOfMedicine, visit: https://medicine.yale.edu/profile/dav... and https://www.thebraunlab.org.

Identifying and understanding the key determinants of effective anti-tumor immunity using combined experimental and computational approaches. The Braun Lab employs bulk and single-cell genomic approaches to uncover interactions between somatic alterations and immune infiltration, and to dissect the tumor-immune microenvironment. The successful development of novel immunotherapeutics will depend in large part on enhancing our understanding of human tumor immunology using patient-derived model systems. Renal cell carcinoma (RCC) is an immunotherapy-responsive cancer that can serve as a model system for understanding key anti-tumor immune determinants in a human system. Collaboratively translating our laboratory findings into early “signal-finding”, investigator-initiated phase 1 clinical trials to advance care for patients with advanced cancer.

0:00 The Braun Lab
0:36 What are they studying?
1:16 How are they studying it?
2:39 Where might this research lead?