Ibogaine Synthesis & How It Might Solve the Opioid Crisis / Treat Addiction | Psychedelic Science

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This video explains biochemistry, organic synthesis and physiological effects - including pre-clinical research on mice/ rats - of ibogaine, ibogamine and other related molecules which might prove useful as the need for effective therapies against substance use disorder and other addiction disorders increase.

00:00 Ibogaine, a magic bullet against addiction?
01:08 Iboga bark: The root of ibogaine & friends
03:11 Effects in the body and similarities to other psychedelics or substances
06:26 Ibogaine's efficacy in heroin addiction
07:21 Safety risks (cardiotoxicity, neurotoxicity)
08:57 How to master any scientific topic- easy and free!
10:18 18-MC (18-methoxycoronaridine): A safer ibogaine?
13:12 TBG (tabernanthalog): An even safer and easier-to-synthesize ibogaine
15:00 How do we test hallucinations, heroin/ alcohol dependency or depression?
21:21 Outlook on MindCure, ibogaine treatment clinics and federal/state priorities
22:52 Synthesis of ibogaine and ibogamine (organic chemistry)
28:38 Synthesis of 18-MC (organic chemistry)

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Key references:
- DARK Classics in Chemical Neuroscience: Ibogaine | ACS Chem. Neurosci. 2018, 9, 2475
- Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice | J. Food. Bioact. 2018, 3, 111
- A systematic literature review of clinical trials and therapeutic applications of ibogaine | Journal of Substance Abuse Treatment 2022, 138, 108717
- Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes| Front. Pharmacol., Sec. Neuropharmacology 2018, 9: 00529
- The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation | Molecules 2015, 20, 2208
- 18-Methoxycoronaridine (18-MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action | Annals of New York Academy of Sciences 2000, 914, 369
- A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature 2021, 589, 474
- The Total Synthesis of (±)-Ibogamine and of (±)-Epiibogamine | JACS 1965, 87, 2073
- Total synthesis of ibogaine, epiibogaine and their analogues | Tetrahedron 2012, 68, 7155
- Gram-Scale Total Synthesis of (±)-Ibogamine | Org Lett 2023, 25, 4567
- Chemical Synthesis and Biological Evaluation of 18-Methoxycoronaridine (18-MC) as a Potential Anti-addictive Agent | Current Med Chem CNS Agents 2001, 1, 113

Some recommended books on organic synthesis:
- Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
- Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
- Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
- Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
- Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
- Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)