Скачать или смотреть Lecture on Introduction to Hepatology: Liver Function, Bilirubin Metabolism & Jaundice | MBBS

This introductory lecture provides a foundation in hepatology, covering liver anatomy, physiology, and the pathophysiology of jaundice, essential for MBBS students. Originally delivered as an MBBS Class (2021-2022 Batch) lecture at Santiniketan Medical College & Hospital, this video explores:

Liver Anatomy & Function:
Overview: Largest organ, dual blood supply [00:14, 00:30].
Functions: Excretory, metabolic, storage, detoxification, synthesis [02:08].
Structure: Lobes, segments, hepatocyte function, Kirman hexagon, Rappaport model [06:16, 07:10].
Bile & Bilirubin Metabolism:
Bile Composition: Bile salts, pigments, cholesterol [11:48].
Bilirubin Pathway: Hemoglobin breakdown, role of OATP/UGT enzymes, conjugation, MRP2 transport, fate in intestine (urobilinogen, stercobilinogen) [12:17, 21:06].
Jaundice (Hyperbilirubinemia):
Definition: Clinical jaundice [29:22].
Types: Conjugated vs. Unconjugated hyperbilirubinemia [31:13].
Patterns: Obstructive jaundice [22:49], differentiating Hepatocellular vs. Cholestatic jaundice [33:30].
Liver Function Tests (LFTs) & Liver Injury:
Key Enzymes: ALT, AST, Alkaline Phosphatase (ALP), GGT [24:51].
LFT Interpretation [38:36].
Causes of Unconjugated Hyperbilirubinemia [39:20].
Causes of Hepatocellular Injury (e.g., Viral Hepatitis, Drug-Induced Liver Injury - DILI) [41:31].
Cholestasis: Intrahepatic vs. Extrahepatic causes [45:13].
Genetic Syndromes:
Conjugated Hyperbilirubinemia: Rotor syndrome, Dubin-Johnson syndrome [15:14].
Unconjugated Hyperbilirubinemia: Crigler-Najjar syndrome, Gilbert syndrome [15:53].
Keywords: Hepatology, Liver Anatomy, Liver Function, Liver Function Tests (LFTs), Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), Gamma-Glutamyl Transferase (GGT), Bile Metabolism, Bilirubin Metabolism, Jaundice, Hyperbilirubinemia, Conjugated Bilirubin, Unconjugated Bilirubin, Hepatocellular Jaundice, Cholestatic Jaundice, Obstructive Jaundice, Liver Injury, Viral Hepatitis, Drug-Induced Liver Injury (DILI), Gilbert Syndrome, Crigler-Najjar Syndrome, Dubin-Johnson Syndrome, Rotor Syndrome, Gastroenterology, Internal Medicine, MBBS Lecture, Santiniketan Medical College.



SANTINIKETAN MEDICAL COLLEGE & HOSPITAL
Real Classroom Demonstration/Lecture
On: MEDICINE by Dr. Amritendu Mandal
(MBBS Batch: 2021-22)
Conducted on: 29-04-25