Pharmacokinetics - Part 2: Lipophilic and Hydrophilic drugs

Whether a drug is lipophilic or hydrophilic has a great effect on its pharmacokinetic properties, especially regarding its distribution, metabolism, and excretion. If a hydrophilic drug is present in the circulation, it doesn’t diffuse through the cell membrane and is, therefore, poorly absorbed by the surrounding tissue. Instead, hydrophilic substances are excreted rapidly from the body.

Outline:
00:00 - Phases of pharmacokinetics
01:11 - Excretion
02:16 - First-Pass-Effect
03:45 - Metabolism rate
04:16 - Distribution

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