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Infective endocarditis is a serious infection of the heart's inner lining and valves, often affecting patients with pre-existing heart conditions or indwelling prosthetic materials.

Clinical presentation may include persistent fever, heart murmurs, splenomegaly, and cutaneous signs like petechiae or Osler's nodes. The infection is typically caused by organisms like Staphylococcus aureus, Streptococcus viridans, or Streptococcus pneumoniae.

Key investigations involve blood cultures and echocardiography, with diagnosis based on the Modified Duke's criteria. Management involves empiric intravenous antibiotics and potential surgical intervention depending on factors like valvular dysfunction.