Скачать или смотреть Unlocking Ovarian Cancer Survival: Spatial Proteomics Reveals Immune Cell Secrets

Ovarian cancer, high-grade serous ovarian cancer, spatial proteomics, immune cells, tumor microenvironment, overall survival, prognosis
Dive into groundbreaking research on high-grade serous ovarian cancer (HGSOC), where spatial proteomics uncovers how immune cell positioning and metabolic states near tumor cells predict patient survival. This study from iScience explores CD66+ cells, cytotoxic CD8 T-cells, Tregs, and more, showing how proximity to tumor boundaries influences outcomes. Learn about the tumor microenvironment's role in therapy strategies and why spatial profiling matters for better prognosis in gynecological malignancies.
Key findings include improved survival with CD66+ cells within 50μm of tumors and CD8 T-cells within 10μm, while certain proximities to low-metabolic tumor cells worsen outcomes. Discover implications for targeted therapies in ovarian cancer treatment.
Perfect for medical professionals, researchers, and patients interested in cancer research advancements.