Скачать или смотреть Challenges in developing dengue vaccine

🦟 Welcome to our channel! 🌍 In today's video, we delve into the intricate world of developing vaccines for Dengue, a viral disease wreaking havoc in tropical and subtropical regions worldwide. With an estimated 400 million infections annually, the quest for a comprehensive Dengue vaccine has encountered several hurdles.

🔍 Challenges Explored:
1. Complexity of the Dengue Virus: Learn about the four distinct serotypes and the difficulty in creating a vaccine that provides robust immunity against all.
2. Antibody-Dependent Enhancement (ADE): Understand how ADE complicates vaccine development and the need for a balanced immune response.
3. Lack of an Animal Model: Explore the challenges posed by the absence of an ideal animal model for Dengue, hindering pre-clinical trials.
4. Immunological Challenges: Uncover the complexities of the immune response to Dengue and the hurdles in developing a protective vaccine.
5. Global Distribution and Variability: Delve into the impact of Dengue's prevalence in diverse regions, complicating vaccine development tailored to specific populations.

🌐 Current Solutions:
Discover Dengvaxia®, the first licensed tetravalent Dengue vaccine, offering protection against all four serotypes. However, understand the associated risks and the World Health Organization's guidelines for its use.

🔬 Future Prospects:
Explore the landscape of other Dengue vaccines currently under development and undergoing clinical trials to assess safety and efficacy.

👩‍⚕️ Join us in unraveling the complexities of Dengue vaccine development, understanding the challenges, and staying updated on the progress toward a safer, healthier future.

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