Скачать или смотреть Microbiology 128 = Factors Affecting Microbial Spoilage of Pharmaceutical Spoilages (Part-3)

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The action or process of spoiling, especially the deterioration of food and other perishable goods. • Any change which renders a product unacceptable for human consumption. • Complex event in which a combination of microbial and biochemical activities may interact. • One of the major reasons that led to preservation. • MICROBIAL SPOILAGE: This refers to damage to food, pharmaceutical products that is caused by microorganisms (bacteria, moulds and yeasts). Microorganisms can grow in almost all kinds of food products. As micro-organisms occur everywhere around us, there is always a risk of microbial spoilage.

PHARMACEUTICAL SPOILAGE • There are several factors that cause pharmaceutical spoilage: Mainly, we study microbial spoilage of pharmaceutical products. PHYSICAL-CHEMICAL MICROBIAL Deterioration of pharmaceuticals due to physical factors like heat, temperature, evaporation, etc. Deterioration of pharmaceuticals due to chemical reactions like oxidation, reduction, hydrolysis, photolysis, ionization, etc. Deterioration of pharmaceuticals due to contamination of any microbial cell like bacteria, fungi, moulds, etc.

Factors affecting microbial spoilage of pharmaceutical products -

(01) Nutritional Factors. Microorganisms utilize many formulation components as substrates for biosynthesis & growth.
(02) Water - It is the most important cause of the survival and growth of micro-organisms.
(03) Storage Temperature. ...
(04) pH. ...
(05) Packaging Design.

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