Non-animal method with regulatory approval for evaluating hormone potency awarded 3Rs Prize

This year’s NC3Rs 3Rs Prize has been awarded to Dr Francesco Nevelli at Merck for a publication describing the development of an in vitro assay for testing follicle-stimulating hormone product potency. The in vitro method was approved by regulators for use in potency testing, at best replacing tens of thousands of animals annually.

Dr Lorna Ewart, Emulate Inc was highly commended for a paper analysing the predictability of an organ-on-a-chip device to determine liver toxicity. In the largest characterisation study of its kind, the paper showed the device had increased sensitivity in identifying toxic therapeutics compared to both current in vitro methods and in vivo studies.

Find out more about this year's 3Rs Prize, including links to the winning papers: https://nc3rs.org.uk/news/non-animal-....

The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is a UK-based scientific organisation dedicated to helping the research community worldwide to replace, refine and reduce the use of animals in research. Primarily funded by the UK Government, the NC3Rs is also supported by the charitable and private sectors. It collaborates with organisations from across the life sciences sector, nationally and internationally, including universities, industries, other research funders and regulatory authorities.

For more information about the NC3Rs: http://www.nc3rs.org.uk.