High altitude pulmonary edema HAPE

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High altitude pulmonary edema is characterized by inhomogeneous pulmonary vasoconstriction in response to reduced oxygen concentration in the inhaled air at high altitude. It may be noted that oxygen is one of the most potent pulmonary vasodilators, which is used therapeutically in the management of chronic pulmonary hypertension by way of nocturnal oxygen therapy. In high altitude pulmonary edema, the inhomogeneous pulmonary vasoconstriction leads to elevated pulmonary capillary pressure and leakage of fluid into the alveoli. This is in fact a form of non-cardiogenic pulmonary edema.

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