Скачать или смотреть Arias Stella Reaction; hormone-induced change in the endometrial glands,

The Arias-Stella reaction is a benign, hormone-induced change in the endometrial glands, typically associated with pregnancy or exposure to high levels of progesterone. It is named after the pathologist Javier Arias-Stella, who first described it in 1954.

🧬 What Is the Arias-Stella Reaction?
It is a non-neoplastic (non-cancerous) change in the endometrial glandular epithelium.

Triggered by elevated progesterone levels, either from:

Normal intrauterine pregnancy

Ectopic pregnancy

Trophoblastic disease (e.g., molar pregnancy)

Hormonal therapy (e.g., progestin-containing IUDs or medications)

🔬 Histological Features
Nuclear enlargement

Hyperchromasia (dark-staining nuclei)

Irregular nuclear contours

Cytoplasmic vacuolation

Pseudonuclear inclusions

These changes can mimic endometrial carcinoma, making accurate diagnosis essential to avoid overtreatment.

🧠 Clinical Significance
Not a disease, but a reactive process

Often found incidentally during endometrial biopsy or curettage

Important to distinguish from malignancy, especially in reproductive-age women or those with abnormal uterine bleeding

🧪 Diagnostic Context
Seen in:

Ectopic pregnancies (as a clue when no intrauterine pregnancy is found)

Gestational trophoblastic disease

Hormonal therapy follow-up

Diagnosis confirmed by histopathology

#ectopicpregnancy