Скачать или смотреть HCN channel, KCNH channel

These are structures of cytoplasmic regions of HCN channel and KCNH channel. HCN channel has a C terminal cyclic nucleotide binding domain with a structure similar to protein kinase A, and is activated by cAMP. Its C-linker region, connecting the 6th transmembrane helix and the cyclic nucleotide binding domain is responsible for tetrnd is activated by cAMP. KCNH channel also has C terminal cyclic nucleotide binding domain, but it is cAMP dependent. This is because its C terminal tail work as an intrinsic ligand, located at the cAMP binding site of the cyclic nucleotide binding domain. N terminal eag domain of KCNH channel interacts with the cyclic nucleotide binding domain, and are located at the periphery of its tetrameric ring.