Скачать или смотреть James Kozloski - The Neural Tissue Simulator: An Ultrascalable Infrastructure for Specifying [...]

James Kozloski, IBM, Thomas J. Watson Research Institute, USA.

Talk at INCF Multiscale Modeling Program Workshop: From cellular/network models to tissue simulation. Stockholm, Sweden May 31st - June 1st, 2012.

This talk provides a description of a neural simulator that employs a novel tissue volume decomposition and a hybrid branched cable equation solver for performing large-scale tissue simulations distributed in blocks over a parallel multithreaded machine. The simulator is capable of solving arbitrary "compartment variables" with channels and synapses targeted to arbitrary sets of these variables using the same topological constraints imposed by branched neuron morphologies embedded in a three-dimensional tissue. Simultaneous calculation of transmembrane voltage and calcium concentrations in a complex tissue of thousands of neurons and millions of voltage- and calcium-dependent ion channels is presented.