Скачать или смотреть Gefaget Gefapixant | A Novel Approach To Managing Refractory Chronic Cough | Targeting P2X3 Receptor

Gefapixant is a medication used to treat refractory or unexplained chronic cough in adults. Here's what you need to know:

Uses:

*Chronic cough treatment*: Gefapixant is designed to help manage coughs that persist despite treatment of underlying conditions or when no underlying cause can be identified.
*P2X3 receptor antagonist*: It works by blocking the action of ATP on P2X3 receptors in the airway, which can trigger coughing.

Side Effects:

Common side effects:
*Taste disorders*: altered perception of taste (dysgeusia), diminished sense of taste (hypogeusia), or loss of sense of taste (ageusia)
Nausea
Upper respiratory tract infection
Headache

How it works:

*Blocking ATP binding*: Gefapixant blocks the binding of extracellular ATP to P2X3 receptors, reducing sensory nerve activation and subsequently, coughing.

Regulatory Status:

*FDA status*: Gefapixant is pending FDA approval for chronic cough treatment in the US.
*Approved in other countries*: Gefapixant has been approved in Japan, Switzerland, and the European Union for treating adult patients with refractory or unexplained chronic cough ¹ ² ³.