Erythropoiesis; Stages of Development and Site of production of red blood cells

Erythropoiesis is the process of producing red blood cells (erythrocytes) from hematopoietic stem cells (HSCs) in the bone marrow. The process of erythropoiesis can be divided into three stages: erythroblastosis, normoblastosis, and reticulocytosis.

Erythroblastosis: This stage is characterized by the formation of erythroblasts from HSCs. Erythroblasts are large cells with a nucleus that divide multiple times to produce smaller cells called normoblasts.

Normoblastosis: During this stage, normoblasts continue to divide and differentiate into smaller cells called reticulocytes. Reticulocytes are immature red blood cells that still contain some organelles, such as ribosomes, and are released into the bloodstream.

Reticulocytosis: In this final stage, reticulocytes mature into erythrocytes, or red blood cells, which are biconcave discs that lack a nucleus and most organelles. Erythrocytes are responsible for transporting oxygen from the lungs to the body’s tissues and removing carbon dioxide from the tissues.

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