How It Works: XCell® ATF Technology

The XCell® ATF System enables the productivity and efficiency boost required to meet the demands of today’s upstream bioprocessing. Dive into the technology and how the components work together to prevent filter clogging, manage increasing cell densities, and extend bioprocess run times.

The XCell® ATF System features a cell retention device with a hollow fiber filter that selectively allows media and target product to pass while retaining cells within the bioreactor. A diaphragm pump, operated by a XCell ATF Controller, circulates the cell suspension between the bioreactor and the filter with bidirectional flow that creates a backflush with each cycle, preventing filter clogging and extending process run times. The XCell® ATF Controller controls and monitors the flow between the ATF device and the bioreactor and ensures that the diaphragm pump operates at the required flow rate as culture cell density (and viscosity) increases.

Learn more about the XCell® ATF System: https://www.repligen.com/products/ups...