Скачать или смотреть 5 Brain Circuits That Make You Hungry — And How to Switch Them Off

This video explains how obesity is fundamentally a brain-based condition—shaped by neurohormonal signals like leptin, ghrelin, and GLP-1—not just a matter of willpower or lifestyle.

Drawing on neuroscience and psychiatry, Dr Sanil Rege breaks down how dysregulation in homeostatic and hedonic systems can drive weight gain, resistance to weight loss, and why most diets fail. You'll also learn how GLP-1 receptor agonists like semaglutide and tirzepatide target brain circuits to support sustainable weight management.

⏱️ Chapter Breakdown: Timestamps
0:00 – Introduction: Why obesity is more than lifestyle
0:54 – The hypothalamic control centre: AgRP vs POMC neurons
1:07 – Leptin resistance and the broken satiety signal
1:49 – The two systems driving Hunger - Homeostatic and Hedonic
3:02 – GLP-1 receptor agonists: how they work on the brain
3:53 – Psychiatric medications and metabolic disruption


The 5 Circuits That Drive Hunger

1. AgRP Neurons (Hypothalamic Accelerator)
– Push appetite strongly when energy is low, overriding satiety signals.

2. POMC Neurons (Hypothalamic Brake)
– Normally suppress hunger, but often fail when leptin resistance develops.

3. Leptin–Satiety Circuit
– Resistance blunts the “I’m full” signal, so the brain keeps driving food intake.

4. Ghrelin–Reward Circuit
– Ghrelin spikes activate orexin and dopamine pathways, making food more rewarding.

5. Dopamine–Hedonic Circuit
– Links eating to pleasure; overactivity leads to craving and overeating even when energy needs are met.

🎓 Educational Highlights:
– Obesity is regulated by both homeostatic (hypothalamic) and hedonic (reward) systems in the brain
– Leptin resistance and ghrelin signalling contribute to persistent hunger
– Diets often fail because of neurobiological adaptations that resist sustained weight loss
– GLP-1 receptor agonists target brain centres involved in satiety, cravings, and inflammation
– Certain psychiatric medications exacerbate metabolic dysfunction—an integrative approach is key
– Practical tools for clinicians include layered pharmacological strategies and patient-centred care

👨‍⚕️ About the Presenter
Dr Sanil Rege is a consultant psychiatrist and educator who has trained over 10,000 mental health professionals. Explore advanced psychiatry and neuroscience-based education at The Academy by Psych Scene.

#ObesityTreatment #GLP1 #Semaglutide #NeurobiologyOfObesity #WeightLossScience #PsychiatrySimplified #DrRege #PsychSceneAcademy #LeptinResistance #GLP1Agonists #BrainBasedMedicine

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