Скачать или смотреть NAIL Color change You should never IGNORE!

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It looks just another simple change of nail color, but is may be very alarming and if ignored it could
costs you your life, this is a sign of advanced kidney diseases, even though sometimes occur in
normal individuals. there are different symptoms and signs that we notice when the kidney is failing,
among these the most obvious once are skin and nail changes which indicates the presence of
serious kidney problem. Cutaneous changes can be observed from the beginning of renal
impairment until the evolution to terminal stage, and after kidney transplantation. About 50–
100% of patients with end-stage renal disease have at least one associated skin or nail change.
Half and half nails or Lindsay's nails were first mentioned by Bean in 1964 and later described
by Lindsay in 1967 in patients with chronic kidney disease. They can occur in various diseases
but also in healthy individuals. whitish discoloration of the proximal half of all nails (50% of
the area), whereas the distal half is red-brown with a sharp demarcation line to the proximal
half. The difference in color persiste despite nail growth, and do not change when applying
vertical pressure on the nail plates. The change may affect one or all nails of the fingers and
toes. Half and half nails are seen in 20-50% of patients with chronic kidney disease, but may
also occur in Crohn's disease, Behçet's disease, pellagra citrullinemia, Kawasaki disease,
cirrhosis, and even in healthy persons. the proximal white band is considered to be caused
by chronic anemia secondary to increased wall thickness of capillaries or overgrowth of
connective tissue between the nail and the bone with the reduction of blood in the
subpapillary plexus. The distal brown band is caused by melanin deposits. Hemodialysis does
not cause improvement in the nail changes, but they can improve or disappear after kidney
transplantation