Pharmacology of ANTIHELMINTHICS (Anthelmintics)-[Part 1]-{Albendazole and Mebendazole}

Classification of Helminths: (0:00)
Indications of Albendazole and Mebendazole: (1:40)
Cross-section of Nematodes: (2:51)
Biochemistry of Helminth's cell: (3:24)
Molecular biology of Helminth's cell: (4:53)
The Mechanism of action of Albendazole and Mebendazole: (6:00)
The ressistance to Albendazole and Mebendazole: (8:47)
Toxicity of Albendazole and Mebendazole: (9:17)
Side effects of albendazole and mebendazole: (9:53)

Antihelminthics or Anthelmintics are a group of antiparasitic drugs that expel parasitic worms aka (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun the parasites) or vermicides (those that kill them). Helminths are classified into roundworms, also known as nematodes and flatworms. As an example of nematodes, we have Ascaris lumbricoides.
Parasitic nematodes cause substantial morbidity and mortality in animals and people globally .
Flatworms are further classified into trematodes aka flukes, for example: Schistosoma mansoni and tapeworms aka cestodes. As an example of cestodes, we have Taenia solium.
Trematodes are flattened oval or worm-like animals. Their most distinctive external feature is the presence of two suckers, one close to the mouth, and the other on the underside of the animal.
Cestodes have no gut or mouth and absorb nutrients from the host's alimentary tract through their tegument, through which gas exchange also takes place.
Worm infection is also known as Helminthiasis.
Drugs used to treat helminthiasis, aka antihelminthics, are classified according to the group of parasites that they affect. So we have Antinematodal Agents; Antitrematodal agents and, lastly, Anticestodal Agents.
In this video, we'll discuss the mechanism of action, indications, and the side effects of two very commonly used antihelminthic drugs, namely Albendazole and Mebendazole.
Albendazole and Mebendazole are, primarily, antinematodal drugs.
5)Both of them are effective against Ascaris lumbricoides which causes ascariasis; Enterobius vermicularis aka human pinworm which causes enterobiasis; and Trichuris trichiura (aka whipworm) that causes trichuriasis.
Albendazole is also effective against Ancylostoma duodenale aka Old World hookworm and Necator Americanus.
Ancylostoma duodenale and Necator americanus are the two human hookworm species that are normally discussed together as the cause of hookworm infection.

Albendazole and Mebendazole also can be effective against some cestodes, for example, Echinococcus granulosus which causes Hydatid disease , Taenia Solium which causes Cysticercosis and neurocysticercosis.
Both agents are effective against Taenia saginata wich causes taeniasis.