Скачать или смотреть Biomarker Identification [Overcoming challenges]

Discovering predictive biomarkers is a cornerstone frontier in personalized medicine. Senior Director of Research and Development at RayBiotech as well as field leader, Dr. Mike Mao provides his insight into what challenges researchers can face as well as how to over come them.

https://www.raybiotech.com/biomarker-...

The discovery of good biomarkers and their translation to the clinic is a challenging and multistep process, for which RayBiotech can provide expertise and a variety of tools to build a tailored solution.

This podcast, featured in Biocompare, covers antibody arrays as screening tools, high-density arrays for biomarker research, and array selection.

The great challenge of biomarker discovery (and its relatively low success rate) is partly attributable to lack of a well-established validation method for candidate biomarkers identified in the initial screen. Using traditional proteomics methods, it can be difficult to follow up on positive hits if no probes are available. This difficulty can be addressed by the utilization of affinity proteomics, in which a pre-qualified antibody pool is applied to both the discovery (screening) process and the downstream stages of verification and validation. Herein lies the core strategy of RayBiotech’s biomarker discovery platform: high-content antibody arrays to tackle protein biomarker candidate discovery, followed by customizable quantitative immunoassays (multiplex or singleplex) to carry out validation studies.