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The use of heterologous steroids for inducible transgene expression is advantageous because, in addition to their favorable kinetics, such molecules will not activate endogenous signaling pathways in the expression host and should therefore have limited toxicity.
Chemically Induced Dimerization is a biological mechanism in which two proteins bind only in the presence of a certain small molecule, enzyme or other dimerizing agent.

Genetically engineered CID systems are used in biological research to control protein localization, to manipulate signaling pathways and to induce protein activation

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