Скачать или смотреть How Smart Microcapsules Release Molecules on Command

Discover how programmable multi-shell microcapsules use pH, enzymes, and temperature to precisely control release behavior. Learn how diffusion physics, stimuli-responsive polymers, and microfluidic engineering combine to create the next generation of intelligent materials. This video introduces programmable microcapsules — tiny core–shell particles that can release their contents in a controlled way when they “sense” the right environment. You will see how these microscale capsules are engineered to respond to pH, temperature, enzymes, and combinations of stimuli, making them powerful tools for targeted drug delivery, precision agriculture, self-healing coatings, and other smart materials. You will learn how single- and multi-shell microcapsules are built, how each shell layer can be tuned to respond to a different trigger, and how this enables sequential or logic-gated release (for example, only releasing if both pH and a specific enzyme are present). The lecture then explains how diffusion through shells actually works, how researchers measure and visualize release profiles, and what it takes to move from elegant lab demonstrations to scalable, regulatory-ready technologies.

What this video covers
What programmable microcapsules are, and why core–shell architectures are so useful for controlled release
How capsule size, shell thickness, and internal structure control release kinetics and stability
Multi-shell and multi-stimuli designs where different layers respond to pH, enzymes, or temperature in a programmed sequence
Key stimuli-responsive materials: pH-sensitive polymers, enzyme-degradable shells, and thermo-responsive hydrogels
How diffusion and shell degradation together determine when and how fast actives leave the capsule
Experimental tools for studying capsules: microscopy, dynamic light scattering, and optical methods to track release profiles
Advanced fabrication via microfluidics and layer-by-layer assembly for nanometer-scale control of shell architecture
Logic-like behavior in “AND/OR” capsules that release only when multiple environmental cues are present
Current challenges: scale-up, batch-to-batch reproducibility, biocompatibility, and regulatory requirements
Future directions toward capsules with feedback, sensing, and autonomous decision-making for smart drug delivery and adaptive materials

Timestamps
00:00 — Introduction: definition and applications
00:30 — Core–shell structure and scale
01:00 — Multi-shell sequential release concept
01:45 — Responsive materials: pH, enzyme, and thermal
03:10 — Diffusion mechanisms and transport equations
04:20 — Mathematical diffusion model
05:20 — Characterization and analysis
06:15 — Layer-by-layer assembly and Boolean logic capsules
07:30 — Manufacturing challenges and scalability
08:30 — Conclusion and future directions

#Microcapsules #ControlledRelease #DrugDelivery #SmartMaterials #Nanotechnology #StimuliResponsivePolymers #BiomedicalEngineering