Neuropathic Pain - NSAIDs, Paracetamol and corticosteroids

Navigating Neuropathic Pain: Arachidonic Acid Pathway & Prostaglandin Management using NSAID, corticosteroids and (for dogs) paracetamol (acetaminophen)
0:00 introduction
1:10 Cox enzymes
3:36 Corticosteroids
5:40 NSAIDS
8:40 Paracetamol
10:14 Grapiprant (prostaglandin receptor antagonists)
11:30 summary and conclusion
In this video, we explore the management of neuropathic pain in animals using drugs that target the arachidonic acid pathway and prostaglandin regulation.
🧠 Understanding the Basics: We'll kick things off by unravelling the fundamentals of the arachidonic acid pathway and how prostaglandin in important in neuroinflammation and neuropathic pain
💊 Exploring Drug Therapies: Discover the arsenal of drugs that influence the arachidonic acid pathway and prostaglandin, including corticosteroids, epidural steroids, and NSAIDs (nonsteroidal anti-inflammatory drugs). Learn how these medications work synergistically with gabapentinoids to improve relief and manage neuropathic pain effectively.
🌡️ The Role of Corticosteroids: Delve into the mechanism of action of corticosteroids and their impact on neuroinflammation. We discuss when corticosteroids such as epidural methylprednisolone can be useful in some neuropathic pain conditions such as lumbosacral disc disease and nerve root entrapment.
🌿 NSAIDs and Neuroinflammation: Explore the world of nonsteroidal anti-inflammatory drugs (NSAIDs) and their role in curbing neuroinflammation. Understand how these medications can be useful in alleviating neuropathic pain.
💊 Paracetamol (Acetaminophen): We'll also discuss the considerations and precautions of paracetamol (acetaminophen) in neuropathic pain management of DOGS. Learn about how it fits into the broader spectrum of treatment options in particular as rescue therapy on “bad days”. (NB Paracetamol / acetaminophen is toxic to cats and should NEVER be used in these species)
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