Скачать или смотреть Achieving Superior Productivity and Purity with TurboCHO™

Title: Next-Gen Bi-specific Antibody Manufacturing: Achieving Superior Productivity and Purity with TurboCHO™

Abstract: Bispecific antibodies (BsAbs), pivotal in next-gen antibody therapies, face complex production challenges including secretion issues, chain imbalance, and impurity formation. GenScript’s TurboCHO technology addresses these with a streamlined workflow—optimizing cell lines, vectors, and media through iterative DOE-driven cycles, and refining chain ratios for enhanced yields. A tailored purification roadmap, powered by various chromatography selection, ensures high purity by leveraging molecular differences among impurities. Real-world cases demonstrate this systematic approach effectively resolves common BsAb production hurdles, supporting diverse formats from concept to clinic.

Speaker: Dr. Darren Yuan
Job Title: Director of Production Support Department, GenScript
Bio: Dr. Darren X. Yuan is the Director of Production Support of Protein Department at GenScript with extensive experience in recombinant protein and antibody production. He specializes in developing high-throughput, high-yield and high-purity protein expression and purification solutions for early-stage protein drug development, and provides expert guidance to protein production teams. Darren led the establishment of GenScript’s TurboCHO™ Platform, significantly advancing protein production capabilities to meet industrial and academic standards.