How to Kill the Heart as Defect (Slay the Spire Guide)

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Today, learn how to kill the heart as Defect in Slay the Spire!


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In this Slay the Spire guide, Baalorlord does an Ascension 5 run with Defect. First, he gives tips on choosing a path and a starting bonus. Later on, he explains his decision for each card he chooses and why it's important to the build. Towards the end, he gears up for an epic Heart fight you don't want to miss. Watch till the end to see if this deck wins it all!

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I use a few mods for Slay the Spire. All of them are Quality-of-Life improvements and do not have any effect on the gameplay. Here are all of the mods I have active:

Slay the Relics Exporter, used for the live stream: https://steamcommunity.com/sharedfile...

Relic Stats, to keep track of how many times the relic effects happened: https://steamcommunity.com/sharedfile...

UI Sliders, to reposition the Discard and Exhaust piles, so that they are not hidden behind the camera: https://steamcommunity.com/sharedfile...

Run History Plus, giving us more info in the Run Summary screen about the run: https://steamcommunity.com/sharedfile...

Map Marks, for path highlighting - here, typically, Green means an easy, intended path, and Orange or Red means a harder path that I might take if I get good rewards: https://github.com/casey-c/mapmarks

Even though I do not use it, I recommend Minty Spire for people looking for various Quality-of-Life improvements: https://steamcommunity.com/sharedfile...

Bestiary, letting me see enemy attack patterns directly in game: https://steamcommunity.com/sharedfile...