Antifungal agents Pharmacology - Amphotericin B: Usmle , Fmge ,Neet pg

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Amphotericin B
An antifungal drug that disrupts fungal cell membranes by reacting with ergosterol. Administered intravenously, intrathecally, or via bladder irrigation. Used to treat severe fungal infections, (e.g., disseminated candidiasis or aspergillosis, fungal meningitis, fungal cystitis). Can cause severe toxicity, including arrhythmias due to QT prolongation, nephrotoxicity (most common adverse effect), electrolyte abnormalities, and hearing loss.

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