Скачать или смотреть Defective protein breakdown contributes to Tenorio Syndrome. Kingston Sedgfield CT Scholar, Anita Lu

How defective protein breakdown contributes to Tenorio Syndrome

New research by the University of Otago’s Department of Biochemistry is looking into how a process (abnormal protein destruction) in cells affects antiviral immune responses and contributes to a recently discovered disease, known as Tenorio syndrome.

The breakdown of proteins is a normal process that occurs within healthy cells. This process is used by cells to control the levels of protein present and therefore how proteins interact with each other. These form the basis of cell signalling pathways which lead to various effects ranging from cell growth to immune responses.

Defects in the specific machinery used to break down proteins in an antiviral immune signalling pathway have been linked to a new disease, called Tenorio syndrome. Tenorio syndrome has a wide range of physical effects, including autoimmunity and intellectual disability. Although specific defects have been identified, little is known about how the defects lead to the development of the disease itself.

This new research aims to answer this question by investigating the link between defects in the protein break-down machinery and the antiviral immune signalling pathway to further our understanding of the underlying molecular basis of Tenorio syndrome.