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Drug-Food Interactions | Doxycycline with calcium and calcium containing products

Doxycycline is a second-generation, broad-spectrum tetracycline antibiotic. It is highly valued in clinical practice due to its high lipophilicity, which allows for excellent tissue penetration and a long half-life, enabling once or twice-daily dosing.

Doxycycline Drug Interaction:

Doxycycline binds to multivalent metal ions (calcium, magnesium, iron, aluminum). Antacids, iron supplements, and dairy products should be taken 2 hours before or 4 hours after the dose to avoid decreased absorption.

Taking Doxycycline along with milk results in chelations and binds with the calcium and decreases the absorption of antibiotic such as doxycycline.

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