Скачать или смотреть PLA-cyanine 5 from PolySciTech used in development of nanoparticles for research on circulation

PLA-cyanine 5 from PolySciTech used in development of nanoparticles for research on circulation and transport

Nanoparticles can be utilized to improve drug delivery to living systems. However, a great deal still remains to be learned about their transportation through the body. Researchers at Yale University and Inha University (Korea) used PLA-CY5 (AV032) from PolySciTech division of Akina, Inc. (www.polyscitech.com) to create fluorescent nanoparticle to track their transport through living systems. This research holds promise to improve nanoparticle delivery systems. Read more: Grundler, Julian, Kwangsoo Shin, Hee-Won Suh, Chang-Hee Whang, and W. Mark Saltzman. "Prolonged Circulation and Enhanced Tumor Uptake of PEGylated Nanoparticles by Manipulation of Nanoscale Surface Topography." (2023). https://chemrxiv.org/engage/chemrxiv/...

“Improving the performance of nanocarriers remains a major challenge in the clinical translation of nanomedicine. Efforts to optimize nanoparticle formulations typically rely on tuning the surface density and thickness of stealthy polymer coatings such as poly(ethylene glycol) (PEG). Here, we show that modulating the surface topography of PEGylated nanoparticles using bottlebrush block copolymer (BBCP) significantly enhances circulation and tumor accumulation providing an alternative strategy to improve nanoparticle coatings. Specifically, nanoparticles with rough surface topography achieve high tumor cell uptake in vivo due to superior tumor extravasation and distribution compared to conventional smooth-surfaced nanoparticles. Furthermore, surface topography profoundly impacts the interaction with serum proteins resulting in the adsorption of fundamentally different proteins onto the surface of rough-surfaced nanoparticles formed from BBCPs. We envision that controlling the nanoparticle surface topography of PEGylated nanoparticles will enable the design of improved nanocarriers in various biomedical applications.”

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Bulk, empty bottles from pandemic-era hand-sanitizer manufacturing and other excess inventory items are available for purchase from Akina, Inc. See more here: https://akinainc.com/polyscitech/Yard...