Ketamine is often grouped together with psychedelics. But pharmacologically and clinically, it behaves very differently, and that difference matters.
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In this video, Paul breaks down why ketamine is not a classic psychedelic, how it compares to psilocybin, and why ketamine’s addiction profile and treatment model deserve special attention as access continues to expand.
WHAT YOU’LL LEARN
Why ketamine is not considered a classic psychedelic
Key differences between ketamine and psilocybin in effects and durability
The core neurobiology distinction between these substances
Why tolerance and dependency risk show up differently with ketamine
How Spravato and at-home models shape use and outcomes
Why integration is central to psychedelic therapy and often missing in ketamine care
CHAPTERS
00:00 Why Ketamine Isn’t a Classic Psychedelic
01:32 The Neurobiology Difference That Changes Everything
03:06 “Critical Learning Period” and Integration "And that when we reopen the critical learning period with a substance like psilocybin as an example"
03:59 Why Ketamine Often Reinforces the Old Drug Paradigm
04:58 Spravato vs At Home Troches "The two most common ways that people are currently using ketamine is Spravato, which I've already talked about"
06:29 So, Is Ketamine a Psychedelic?
ABOUT PAUL F. AUSTIN
Paul F. Austin is the founder of Third Wave and the Psychedelic Coaching Institute, and host of The Psychedelic Podcast. For over a decade, Paul has explored responsible psychedelic use through the lenses of education, harm reduction, and practical integration. His work supports both the general public and practitioners with clear, research-informed perspectives on medicines, mental health, and the ethical skills required to work safely and effectively in this space.
Psychedelic Coaching Institute
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