Скачать или смотреть Bismuth subsalicylate (Pepto-Bismol) pharmacology, GI drugs pharmacology, pharmacology made easy

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💊 Bismuth subsalicylate acts as an antimicrobial, anti-inflammatory, and antisecretory agent. It binds enterotoxins and inhibits their action, reducing intestinal secretions and inflammation.
💊 Bismuth subsalicylate (e.g., Pepto-Bismol) is primarily used for acute diarrhea, including traveler’s diarrhea, and as part of H. pylori eradication regimens.
💊 Bismuth can react with sulfur in saliva and GI tract, producing black-colored tongue and stools — a harmless and reversible effect.
💊 Chronic use or overdose can lead to salicylate toxicity, with symptoms like tinnitus, confusion, and metabolic acidosis.
💊 Like other salicylates, bismuth subsalicylate is contraindicated during pregnancy (especially third trimester) and in children due to Reye’s syndrome risk.
💊 Bismuth subsalicylate contains salicylate, which can increase bleeding risk when combined with anticoagulants like warfarin.
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Chapters:
0:00 - bismuth subsalicylate pharmacology
0:27 - bismuth subsalicylate mechanism of action
1:32 - bismuth subsalicylate pharmacokinetics
2:05 - bismuth subsalicylate side effects
2:37 - bismuth subsalicylate contraindications
3:03 - bismuth subsalicylate drug interactions

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