Скачать или смотреть Why Standing Up Makes You Dizzy: The POTS-Nerve Connection | Long COVID 101

Over 90% of Long COVID patients have cardiovascular symptoms. Nearly one-third have formal POTS diagnosis. For years, they've been told "it's anxiety" or "you're deconditioned."

Now we have the physiological proof: Their sympathetic nerve fibers can't properly recharge after firing—and that's why blood pressure regulation fails.

This clip explains the Recovery Cycle of Excitability (RCE) and reveals the direct electrical link between nerve dysfunction and POTS symptoms.

🔬 COMPLETE EXPLANATION COVERS:
Why 92% had cardiovascular/dysautonomia symptoms
31.7% with formal POTS diagnosis
How sympathetic C fibers differ from sensory fibers
Recovery Cycle of Excitability (RCE) explained
What the "supernormal period" means (and why it matters)
Flat RCE curves in Long COVID patients
Membrane depolarization: the battery that won't recharge
Direct physiological link: depolarized nerves → failed blood vessel constriction → POTS
88% had BOTH sensory and autonomic C-fiber dysfunction
Generalized small fiber system failure

🔑 KEY INSIGHT:
"If a nerve is partially depolarized, its ability to reliably conduct signals—especially trains of signals needed for sustained responses—is impaired. When you stand up, your sympathetic nerves need to reliably fire to constrict blood vessels in your legs. If these fibers are depolarized and can't transmit those signals, the blood vessels don't constrict properly. Blood pools in the legs, blood pressure to the brain drops, and the heart races to compensate."

💡 TIMESTAMPS:
0:00 - Bringing autonomic dysfunction into focus
0:25 - Over 90% had cardiovascular symptoms
0:50 - Assessing sympathetic fibers differently
1:15 - Recovery Cycle of Excitability (RCE) explained
1:55 - RCE measures nerve "battery recharge"
2:25 - The supernormal period in healthy nerves
2:55 - FINDING: Flat RCE curves (missing supernormal period)
3:20 - What flatness means: membrane depolarization
3:45 - Why depolarized nerves cause POTS symptoms
4:05 - 88% had both sensory AND autonomic dysfunction

📊 THE AUTONOMIC FINDINGS:
92% had cardiovascular/dysautonomia symptoms
31.7% formal POTS diagnosis
88% had dysfunction in BOTH sensory and sympathetic C-fibers
Flat RCE curves = absent supernormal period
Membrane depolarization = impaired signal reliability

🎓 PERFECT FOR:
POTS patients seeking physiological explanation
People with orthostatic intolerance
Those told "it's just anxiety" or "you're deconditioned"
Researchers studying autonomic dysfunction
Advocates fighting for POTS recognition

🔬 CLINICAL SIGNIFICANCE:
Provides objective measurement of autonomic nerve health
Explains why standing triggers symptoms
Links electrical dysfunction to blood pressure regulation failure
Shows POTS is neurological, not psychological
Demonstrates generalized small fiber system involvement

This is a clip from Long COVID 101 – Episode 2: "Hidden Nerve Damage in Long COVID?"

📺 WATCH THE FULL EPISODE (37 min):
   • 88.9% of Long COVID Patients Have Nerve Da...  

Complete episode includes:
✅ 88.9% had measurable C-fiber dysfunction overall
✅ Spontaneous firing, sensitization, signal amplification
✅ Activity-dependent slowing (mirror image patterns)
✅ Complete RCE methodology and findings
✅ Why multi-system symptoms all trace to small fibers
✅ Treatment implications and future research directions

📚 UNDERSTANDING RCE:
Recovery Cycle of Excitability measures how quickly a nerve fiber can fire again after just firing. It's incredibly sensitive to the nerve's resting membrane potential—the electrical charge that determines if the nerve is "ready to fire" or "exhausted."

Healthy nerves: Show a supernormal period (temporarily MORE excitable = robust recovery)
Long COVID nerves: Flat curves (missing supernormal period = depolarization/dysfunction)

💭 THE BIG QUESTION:
Could RCE monitoring become an early warning system for detecting nervous system dysfunction before it becomes debilitating—not just for Long COVID, but for all post-viral and chronic fatigue syndromes?

⚠️ DISCLAIMER: This podcast blends fictional dialogue with real scientific insights for educational purposes. Always consult healthcare professionals for medical advice.


🎙️ Produced by: Long COVID 101
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